Tissue factor-dependent blood coagulation is enhanced following delivery irrespective of the mode of delivery

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Tissue factor-dependent autoactivation of human blood coagulation factor VII.

We recently showed that single-chain zymogen factor VII is converted to two-chain factor VIIa in an autocatalytic manner following complex formation with either cell-surface or solution-phase relipidated tissue factor apoprotein (Nakagaki, T., Foster, D. C., Berkner, K. L., and Kisiel, W. (1991) Biochemistry 30, 10819-10824). We have now performed a detailed kinetic analysis of the autoactivati...

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Factor XI-dependent reciprocal thrombin generation consolidates blood coagulation when tissue factor is not available.

OBJECTIVE Feedback activation of factor XI by thrombin is a likely alternative for tissue factor-dependent propagation of thrombus formation. However, the hypothesis that thrombin can initiate and propagate its formation in a factor XI-dependent and platelet-dependent manner has not been tested in a plasma milieu. METHODS AND RESULTS We investigated thrombin generation in recalcified platelet...

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ژورنال

عنوان ژورنال: Journal of Thrombosis and Haemostasis

سال: 2007

ISSN: 1538-7933,1538-7836

DOI: 10.1111/j.1538-7836.2007.02767.x